So gentle reader, the ides of August are upon us.  That means that goals slated for accomplishment this year had better be in sight! If you have a clinical candidate in your goals, you had better have your scale-up worked out and your animals ordered for those remaining pharmacology studies and dose ranging tox and PK. If you have programs finishing up, hopefully the screening campaigns are done, so you can order resupply on the hits and you can validate them before the end of the year and have a chance of getting the work done to start on the hit to lead for next year.  If those hit-to-lead campaigns are supposed to move into lead optimization you had better be seeing your primary assay start to produce results that promise the hope of seeing in vivo activity.  That and the annual ritual of filling out your budget like a kid filling out his Christmas list only to have Santa turn into the Grinch and arbitrarily cut 50% off the top.

Ah the Ides of August!

So I want to offer you some help.  If you are stuck optimizing your leads, Victrix can help with structure based and ligand based methods.  If new chemical matter is what you are looking for, we can pull bioisosteres out that will surprise you. Virtual screening, both structure and ligand based can help bring ideas into play that you haven't thought of.  We can help you mine your HTS data and determine false positives and flag potential false negatives for follow-up.  We can build custom PK and tox models to help you out of your DMPK problems.  

It's so cheap, you can't afford not to. Call us for an evaluation.  We will work with your chemists and biologists to give you access to a state of the art computational chemistry and molecular modeling department that uses the same tools as big pharma and the best computational departments with expertise that is the best in class.  I'm sure you are thinking that you can't afford it.  But you can.  You don't need it all the time.  You only pay for access to the tools and expertise you need, when you need it.  Save you head count for another medicinal chemist who can make compounds or another biologist who can generate precious, precious data.  Let us be your computational group.  The only thing you might miss is that sinking feeling when this year’s goals slip out of sight, and you weren't really looking forward to that anyway, were you?




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I am fortunate person. I really have a life filled with tremendous blessings.  My wife, who had cancer, is cancer free, healthy and starting her own business venture. When I was laid off, I had sufficient funds to start this consulting business, which is getting traction and attracting high quality clients.  

I am really impressed with one new client in particular: Collaborative Drug Discovery.  They truly are collaborative.  I have become involved with one of their collaborative efforts and am enjoying it tremendously. We had our first meeting on Monday and lets just say that people from all over the world were involved. While the jetpacks we were promised never materialized, we have something that makes them unnecessary. The true power of the internet is being realized.  We can communicate with people all over the world, work together, and securely share data all from the comfort of our homes.  

I have been able to assemble a computational chemistry work suite for under $2,000.  The negotiated software license agreements were easy to negotiate.  The ability of a decentralized team of experts to put together a dynamic program are now in place.  We are in a position to reap the benefits.  This is particularly important for my discipline.  Computational chemistry used to be expensive and require a company to hire a full time expert.  Now you can bring one on (me for example) and have the benefit of decades of experience for a reasonable price and only pay for the services you actually need.  Pretty cool, huh? I think so.  Distance is no longer a barrier.  I can work with anyone in the world. Web meetings make it possible to sit in on meetings in Moscow, or Brisbane.  Your can get project information and share results with people in Buenos Aires, or Naples. 

The future is here, and I like it!