This would fall in to the category of things I find mildly disappointing, except for the fact that doctors have apparently prescribing Bexarotene to their Alzheimer’s patients off label. Having been at Ligand for a good portion of its troubled history, I know that Bexarotene has some pretty nasty side effects. Hyperlipidemia that is sufficiently elevated to cause pancreatitis. I have very serious reservations about off label prescriptions, particularly based on one study. I know that Alzheimer’s is a horrible disease, but remember our friend Hippocrates, first do no harm. This clearly falls into the doing harm part of the equation.
Let’s remember A MOUSE IS NOT A HUMAN.
Sorry for shouting.